Scientific presentations
White papers
Scientific posters
20th Annual PEGS Boston Conference and Expo.
May 13, 2024 Author: Pete Leland, Nicola Bonzanni
A deep learning tool and service for next-generation antibody humanization
June 4, 2024 Author: Katharina Waury , Stefan Lelieveld, Sanne Abeln, Henk-Jan van den Ham
Comparison of sequence- and structure-based antibody clustering approaches on simulated repertoire sequencing data
20th Annual PEGS Boston Conference and Expo.
May 13, 2024 Author: Gergana Bounova, Paul Saari, Amelie Wanney, Donovan McGinley-Colman, Lena Schimmelpfennig, Dennis Zimmer, Steffen Massa, Jacob Marvel, Jacob Shreffler, Pete Leland, Nicola Bonzanni
Genovac’s humanization powered by ENPICOM: A deep learning tool and service for next generation antibody humanization
Biologics by Oxford Global
March 14, 2024 Author: Néstor Vázquez Bernat
Solving big data challenges in therapeutic discovery
Antibody Engineering & Therapeutics.
December 14, 2023 Author: Néstor Vázquez Bernat
Advances in lead discovery with high-throughput sequencing data and in-silico models
PEGS Europe.
November 14, 2023 Author: Piotr van Rijssel
Data-driven discovery made easy, scalable, and ready for the ML era
Illumina, Cerba Research, and ENPICOM logos.
November 16, 2023 Author: Illumina & Cerba Research & ENPICOM
Navigating the immune repertoire: A deep dive into applications, workflows, and new sequencing chemistries
June 6, 2023 Author: Néstor Vázquez Bernat
A recipe for data-driven therapeutic discovery: Advances, ingredients, and applications
May 15, 2023 Author: Piotr van Rijssel
Data-driven lead discovery for modern wet-lab platforms
March 30, 2023 Author: Jelle van Schooten
Seamless integration of antibody sequencing and screening data for lead discovery
February 9, 2023 Author: ENPICOM & The Antibody Society
Setting up Rep-Seq for antibodies: There and back again
Antibody Engineering & Therapeutics
December 5, 2022 Author: Piotr van Rijssel
Integrated data analysis for antibody discovery
Characterization of the T cell receptor repertoire and melanoma tumor microenvironment upon combined treatment with ipilimumab and hTERT vaccination.
September 11, 2022 Author: Ellingsen EB, Bounova G, Kerzeli I, Anzar I, Simnica D, Aamdal E, Guren T, Clancy T, Mezheyeuski A, Inderberg EM, Mangsbo SM, Binder M, Hovig E, Gaudernack G
Characterization of the T cell receptor repertoire and melanoma tumor microenvironment upon combined treatment with ipilimumab and hTERT vaccination
Proteogenomic analysis of the autoreactive B cell repertoire in blood and tissues of patients with Sjögren's syndrome.
February 10, 2022 Author: Broeren MGA, Wang JJ, Balzaretti G, Groenen PJTA, van Schaik BDC, Chataway T, Kaffa C, Bervoets S, Hebeda KM, Bounova G, Pruijn GJM, Gordon TP, De Vries N, Thurlings RM
Proteogenomic analysis of the autoreactive B cell repertoire in blood and tissues of patients with Sjögren’s syndrome
PEGS Europe
November 14, 2022 Author: Néstor Vázquez Bernat
Minimizing lead optimization with data-driven antibody discovery
Anti body development process
April 10, 2021 Author: Néstor Vázquez Bernat, Josine oude Lohuis, Henk-Jan van den Ham
High-throughput Sequencing Technologies are Revolutionising Antibody Discovery
Digital week: Antibody Technologies and Applications.
September 27, 2022 Author: Nicola Bonzanni
Raising the bar for NGS-powered antibody discovery with flexible enrichment, accurate developability, and interactive phylogenetic analysis
Immunome-based diagnostic process infographic: (A) Blood drawn and genes sequenced. (B) Patterns identified to develop condition-specific test. (C) Multiplexed assay detects multiple conditions. (D) Classifier refines over time for improved diagnosis.
March 15, 2021 Author: Arnaout RA, Prak ETL, Schwab N, Rubelt F, Adaptive Immune Receptor Repertoire Community
The Future of Blood Testing Is the Immunome
Antibody Engineering & Therapeutics Europe
June 24, 2022 Author: Lorenzo Fanchi
Tracking antibody enrichment in display libraries with the IGX Platform
On-demand webinar
June 28, 2022 Author: ENPICOM
Meet IGX-Track: Our unique new App for seamless analysis of antibody display data
March 21, 2022 Author: Néstor Vázquez Bernat
Select better antibodies using high-throughput structural liability predictions 
January 18, 2022 Author: Piotr van Rijssel
Discovery and prioritization of novel antibodies with advanced repertoire analysis and exposed liability predictions
On-demand webinar
October 14, 2021 Author: ENPICOM & Viroclinics-DDL
From sample to discovery: Advancing your research with full-service immune repertoire sequencing & analysis
Two ENPICOM white papers, open and closed.
November 2, 2023 Author: ENPICOM
Simply select better antibodies with the IGX Platform
Scatter plot of mCRPC showing generation probability (log2) on the y-axis and mean cluster frequency on the x-axis.
November 16, 2020 Author: Donjete Simnica, Minke Smits, Edith Willscher, Lorenzo F. Fanchi, Iris S.H. Kloots, Inge van Oort, Winald Gerritsen, Niven Mehra, and Mascha Binder
Responsiveness to Immune Checkpoint Inhibitors Is Associated With a Peripheral Blood T-Cell Signature in Metastatic Castration-Resistant Prostate Cancer
An infographic showcasing the degree of sharedness by the generation probability.
August 13, 2020 Author: Kilian Schober, Pim Fuchs, Jonas Mir, Monika Hammel, Lorenzo Fanchi, Michael Flossdorf, Dirk H. Busch
The CMV-Specific CD8+ T Cell Response Is Dominated by Supra-Public Clonotypes with High Generation Probabilities
An infographic about the next‐generation immunosequencing reveals pathological T cell architecture in autoimmune hepatitis.
July 21, 2020 Author: Christoph Schultheiß, Donjete Simnica, Edith Willscher, Anna Oberle, Lorenzo Fanchi, Nicola Bonzanni, Nils H. Wildner, Julian Schulze‐Zur‐Wiesch, Christina Weiler‐Normann, Ansgar W. Lohse, Mascha Binder
Next‐generation immunosequencing reveals pathological T cell architecture in autoimmune hepatitis
March 16, 2020 Author: Kilian Schober, Florian Voit, Simon Grassmann, Thomas R. Müller, Joel Eggert, Sebastian Jarosch, Bianca Weißbrich, Patrick Hoffmann, Lisa Borkner, Enzo Nio, Lorenzo Fanchi, Christopher R. Clouser, Aditya Radhakrishnan, Lorenz Mihatsch, Philipp Lückemeier, Justin Leube, Georg Dössinger, Ludger Klein, Michael Neuenhahn, Jennifer D. Oduro, Luka Cicin-Sain, Veit R. Buchholz & Dirk H. Busch
Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection
Line graph showing tumor size (mm²) on the y-axis and time after start of treatment (days) on the x-axis, with two lines representing control and treated groups.
February 12, 2020 Author: Sjoerd Klarenbeek, Chris W. Doornebal, Sjors M. Kas, Nicola Bonzanni, Jinhyuk Bhin, Tanya M. Braumuller, Ingrid van der Heijden, Mark Opdam, Philip C. Schouten, Kelly Kersten, Jos Jonkers
Response of metastatic mouse invasive lobular carcinoma to mTOR inhibition is partly mediated by the adaptive immune system
July 25, 2019 Author: Donjete Simnica, Nuray Akyüz, Simon Schliffke, Malte Mohme, Lisa v.Wenserski, Thorben Mährle, Lorenzo F. Fanchi, Katrin Lamszus & Mascha Binder
T cell receptor next-generation sequencing reveals cancer-associated repertoire metrics and reconstitution after chemotherapy in patients with hematological and solid tumors
August 21, 2019 Author: Donjete Simnica, Simon Schliffke, Christoph Schultheiß, Nicola Bonzanni, Lorenzo F. Fanchi, Nuray Akyüz, Barbara Gösch, Christian Casar, Benjamin Thiele, Janina Schlüter, Ansgar W. Lohse and Mascha Binder
High-Throughput Immunogenetics Reveals a Lack of Physiological T Cell Clusters in Patients With Autoimmune Cytopenias
Diagram of T-cell clusters.
January 24, 2019 Author: Thorben Mährle, Nuray Akyüz, Pim Fuchs, Nicola Bonzanni, Donjete Simnica, Ulrich Germing, Anne Marie Asemissen, Johann-Christoph Jann, Florian Nolte, Wolf-Karsten Hofmann, Daniel Nowak, and Mascha Binder
Deep sequencing of bone marrow microenvironments of patients with del(5q) myelodysplastic syndrome reveals imprints of antigenic selection as well as generation of novel T cell clusters as response pattern to lenalidomide