Platform ecosystem

IGX Platform Apps

Pick and choose from our specialized Apps to compose the desired end-to-end workflow to answer your biological questions

Download our white paper
Clone annotation

IGX-Profile offers a scalable and intuitive way to go from raw data to annotated clones. It annotates B and T cells from multiple species sequenced with any technology. It supports plate- and microfluidics-based protocols, linking paired chains using barcodes and UMI error correction to ensure data of the highest quality.

Quality control

IGX-Inspect enables quality control of FASTQ files and profiled samples. Different interactive visualizations are available, depending on the data type. For FASTQ data: Read Length Distribution and Average Base/Sample Quality. For Collections generated using IGX-Profile, the Read Fate can be inspected.

Repertoire overview

IGX-Explore generates intuitive visualizations that provide insight into the dynamics of the immune system response. It includes several analyses with interactive plots: V/J Gene Usage, Diversity Measures, and CDR3 Length Distribution.

Clustering

IGX-Cluster identifies sequence clusters based on user-defined parameters such as heavy and/or light CDR3 similarity, gene usage, and CDR3 length. Clustering samples from different sequencing technologies provides the ideal setup for important discovery tasks like candidate selection and hit expansion.

Phylogeny

IGX-Branch is a 2-stage rocket. First, clusters are prioritized based on their size and content, and phylogenetic trees are computed for clusters of interest. Second, interactive tree visualizations are generated which link visual variables such as color, shape and size to available assay data, providing a versatile system to pick antibody candidates for follow-up analysis.

Enrichment analysis

IGX-Track provides a fast, flexible way to discover a diverse set of highly enriched candidates from display screening. Freely join, intersect, and subtract datasets to compose the analysis of any panning campaign design, no matter the complexity. Explore the results through interactive tables and graphs, where any metadata or assay data can be integrated and combined with powerful filtering and sorting options to select the most promising antibody candidates.

Developability

IGX-Annotate enables high-throughput structural modeling of antibodies to accurately identify and annotate exposed liabilities. It provides an assessment of the developability of candidates by comparing the characteristics of your antibodies to those of clinically approved antibodies.

IGX Platform functionality at a glance

Fitted to your requirements

Rapidly implement solutions that are tailored to your discovery workflow. Our team has years of experience in immunology, bioinformatics, and software engineering to help you make the most of your repertoire sequencing data. Through our Last Mile Service, we can ensure seamless integration of custom workflows into our scalable IGX Platform, providing continuous support and adapting to your evolving project requirements. 

A person writing code on a laptop using multiple monitors.