Platform ecosystem

IGX Platform Apps

Pick and choose from our specialized Apps to compose the desired end-to-end workflow to answer your biological questions

IGX Platform Architecture
IGX-Profile

IGX-Profile performs clone identification and quantification from raw sequencing data. It supports NGS and Sanger data from B and T cells and offers references for multiple species. Using state-of-the-art error correction, it accurately reconstructs (full-length) receptor sequences.

MiXCR processes big immunome data from raw immune receptor sequencing data to quantitated clonotypes. It extracts both T and B cell receptor repertoires and assembles clonotypes, while correcting for false diversity, arising from PCR and sequencing errors.

IGX-Inspect

IGX-Inspect enables quality control of FASTQ files and profiled samples. Different interactive visualizations are available, depending on the data type. For FASTQ data: Read Length Distribution and Average Base/Sample Quality. For Collections generated using IGX-Profile, the Read Fate can be inspected.

IGX-Explore

IGX-Explore generates intuitive visualizations that provide insight into the dynamics of the immune system response. It includes several analyses with interactive plots: V/J Gene Usage, Diversity Measures, and CDR3 Length Distribution.

IGX-Cluster identifies sequence clusters based on user-defined parameters such as heavy and/or light CDR3 similarity, gene usage, and CDR3 length. Clustering samples from different sequencing technologies provides the ideal setup for important discovery tasks like candidate selection and hit expansion.

IGX-Branch is a 2-stage rocket. First, clusters are prioritized based on their size and content, and phylogenetic trees are computed for clusters of interest. Second, interactive tree visualizations are generated which link visual variables such as color, shape and size to available assay data, providing a versatile system to pick antibody candidates for follow-up analysis.

IGX-Notebook provides a user-friendly interface to extend the power of IGX Apps with custom analyses to fit your specific research needs. Use R and Python scripts to gain additional insight from all your (meta)data stored in the IGX Platform, using the same powerful cloud infrastructure as the rest of the platform.

IGX-Annotate enables high-throughput structural modeling of antibodies to accurately identify and annotate exposed liabilities. It provides an assessment of the developability of candidates by comparing the characteristics of your antibodies to those of clinically approved antibodies.

Continuous development

We continuously improve existing and develop new Apps and features to fit your research needs. Read our release notes to discover our latest developments.

What’s new in the IGX Platform?

Fitted to your requirements

We build custom software solutions to perfectly fit your discovery workflow, or help answer specific research questions. Take advantage of ENPICOM’s diverse expertise in immunology, bioinformatics, and software engineers is to make the most of your repertoire sequencing data today.

Software engineering