ENPICOMA deep learning tool and service for next generation antibody humanization
May 13, 2024
Author: Bounova G, Saari P, Wanney A, McGinley-Colman M, Schimmelpfennig L, Zimmer D, Massa S, Marvel J, Shreffler J, Leland P, Bonzanni N
Here, we introduce a cutting-edge, species agnostic service for next-generation humanization of antibodies, based on the novel AIGX generative deep learning model. Through a commercial project focused on the discovery and development of anti-RAGE antibodies, we show that this solution generates humanized mouse and rat sequences with significantly greater success than using traditional methods such as CDR grafting and publicly available algorithms such as BioPhi. Genovac’s capacity to achieve superior results across species and to enable humanization of large numbers of candidates represents a significant advancement in antibody humanization, leading to lowered costs and a shortened timeline to IND filing.
