IGX Platform

IGX specifics

Single-cell sequencing
Single-cell support

IGX Platform 2.0 supports the storage, annotation and analysis of paired receptor chains and includes new search options specifically tailored to the structure of paired receptor data, making it easier than ever to find and analyze your single-cell data.

Comparison searches
Powerful comparison analyses

With IGX-Compare, users can compare any two data sets and easily visualize and prioritize matching clones. For instance, by matching a single clone against an external database or by finding the overlap between two internal patient cohorts.

Flexible at the frontend
Flexible at the frontend

IGX currently supports Illumina FASTQ data from BCR (heavy, lambda, and kappa chains) and TCR (alpha and beta chains) sequencing experiments from both DNA and RNA of human and murine samples, as well as annotated clones from various data sources.

First-in-class clone identification

Correct identification and quantification of receptors is a crucial and fundamental step in the analysis of immune repertoires. Extensive head-to-head benchmarking studies versus popular tools in the field show that IGX-Profile shows superior performance in the correct identification of both B and T cell clones.

Scalable
Scales according to your needs

The IGX Platform automatically scales its resources, which ensures maximal responsiveness and execution performance, irrespective of the amount of data you want to work with.

Secure cloud deployment

The IGX Platform is delivered through a Software as a Service (SaaS) model, hosted centrally and available instantly to every user via their web browser. The SaaS approach eliminates deployment time, substantially reduces maintenance costs and ensures that users always have access to the latest version of the IGX Platform. All communication to and from the platform is encrypted and validated by a certified independent authority in order to ensure secure and private access.

Always up-to-date

The cloud-based IGX Platform allows users to have instant access to the latest version of the platform and its Apps.

Reproducibility through version control

All previous versions of Apps remain available for analyses in order to ensure perfect reproducibility of results and consistency during the entire drug development process.

market authorization
Market authorization support

The IGX Platform has been developed following the principles of the IEC 62304 standard, a framework that facilitates safe design and maintenance of medical device software. The structured lifecycle process ensures reliability of the end-result and reduces the regulatory compliance burden of products developed using the IGX Platform, thereby accelerating the drug development process.

Leverage public databases to enrich your data

Open-access immune receptor repositories contain a wealth of information that can be used for the development of novel drug components and in support of fundamental and translational research on immune responses. IGX-Compare provides a gateway to some of the largest external databases through an intuitive user interface. Users can query their data against hundreds of millions of sequences that have been characterized by researchers worldwide, allowing researchers to efficiently learn more about their clones of interest. The IGX Platform currently provides access to 3 public databases, curated and ready for exploration:

  • The Adaptive ImmuneACCESS Database (ImmuneACCESS) contains billions of BCR and TCR sequences generated by hundreds of researchers across research disciplines.
  • The VDJ database (VDJdb) is a curated database of T-cell receptor (TCR) sequences, many including chain pairing information and with known antigen specificities.
  • The Immune Epitope Database (IEDB) catalogs experimental data on antibody and T cell epitopes studied in humans, non-human primates, and other species in the context of infectious disease, allergy, autoimmunity and transplantation.